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Pcsk9 Education And Research Forum

pcsk9 education and research forum

Alcester

Reducing low density lipoprotein (LDL) cholesterol is the priority in managing patients with severe dyslipidaemia (cholesterol abnormality) and at high risk of cardiovascular (CV) death and disability. Yet even when treated with potent statins, many patients fail to achieve LDL-cholesterol targets and therefore their risk of accelerated atherosclerosis and CV death remains high. This problem is particularly critical in patients with familial hypercholesterolaemia (FH) (the most commonly occurring genetic condition in the world). People with FH typically have very high LDL cholesterol levels on treatment, and consequently, are at very high risk of premature and sudden CV death, myocardial infarction and stroke. Additionally, some patients are unable to tolerate statins – particularly at higher doses – and, therefore, do not achieve LDL-cholesterol goals. What is the importance of PCSK9? Discovered in 2003,1 PCSK9 is a protein made by the liver which increases the removal of LDL receptors from the surface of liver cells. These LDL receptors are critically important in removal of serum LDL-cholesterol from the circulation. People with so-called ‘gain of function’ PCSK9 mutations over-express PCSK9, and therefore have very high plasma levels of LDL cholesterol and are at very risk of atherosclerosis and CV mortality and morbidity.2 In contrast, people with so-called ‘loss of function’ PCSK9 mutations, have very LDL cholesterol levels and reduced risk for heart disease.3 What is PCSK9 inhibition? Different approaches to lowering PCSK9 are now licensed. These include fully human monoclonal antibodies (alirocumab, evolocumab) and a small-interfering RNA therapy (inclisiran). Trials show that these PCSK9 inhibitors reduce LDL cholesterol levels by about 50-60 percent - a significantly greater effect than that achieved with currently available therapies – either when given alone or in combination. These LDL cholesterol lowering effects have been consistently across a broad group of patients, including those with familial hypercholesterolaemia in clinical trials.4 Which clinical settings will benefit from the availability of PCSK9 inhibitors? These treatments offer the potential to reduce cardiovascular risk in patients whose clinical needs cannot be satisfied by current therapy. These include: Patients with familial hypercholesterolaemia – an inherited disorder of lipid metabolism with a very high risk of early CV death or morbidity, if not diagnosed or treated early Patients who cannot tolerate statins, who therefore remain at high risk of CV events such as heart attacks and strokes Patients with established heart disease who have not achieved LDL-cholesterol goals despite current therapies

Courses matching "High Risk"

Show all 139

Qualsafe Level 3 Award in First Response Emergency Care (FREC3)

By Pulse South Coast Ltd - Training & Medical Services

Duration 5 Days Certificate Validity 3 years Course Overview Embark on the journey towards the QA Level 3 Certificate in First Response Emergency Care (RQF), a nationally recognised qualification meticulously crafted for individuals carving a path in emergency services, ambulance operations, event and security medical sectors, or high-risk workplaces. Endorsed by The Faculty of Pre-Hospital Care – The Royal College of Surgeons of Edinburgh and meticulously aligned with the PHEM skills framework at descriptor level D, this qualification serves as a cornerstone for diverse roles in emergency care. Whether you aspire to be an Event Medical Responder, Emergency Care Support Worker, or beyond, this qualification opens doors to a realm of possibilities. Furthermore, the QA Level 3 Certificate in First Response Emergency Care (RQF) seamlessly integrates into a progressive suite of prehospital care qualifications, paving the way towards the esteemed QA Level 6 Diploma in Paramedic Practice (RQF). What’s Covered Delve into the roles and responsibilities of a first responder Navigate through diverse medical emergencies Master the art of patient assessment Acquire proficiency in airway management Learn adult, child, and infant CPR & AED usage Understand Return of Spontaneous Circulation (ROSC) procedures Gain insights into emergency oxygen administration Handle traumatic injuries with confidence Manage catastrophic bleeding scenarios Address cases of shock effectively Navigate through incidents involving poisoning and intoxicating substances Tackle both external and internal bleeding situations Learn techniques for helmet removal Master neck, spine, and pelvic immobilisation procedures Understand and manage environmental exposure cases Address burns and scalds efficiently Learn to handle minor injuries Grasp the essentials of incident reporting Entry Requirements Participants must be at least 17 years old on the first day of training. No additional formal entry requirements exist; however, learners are advised to possess a minimum Level 2 proficiency in literacy and numeracy or equivalent, along with a basic understanding of first aid concepts Course Information Venue: All our 'Open' courses are delivered from our dedicated training venue: Pulse South Coast Ltd, Bentley Wildfowl, Harveys Lane, Ringmer, BN8 5AF On occasion we may use a separate venue, this will be advised on the course booking. Facilities: On your course you will be provided with tea & coffee making facilities and biscuits. We are in a rural location so we recommend brining lunch with you on the day. There is a microwave & fridge on site for your use. There is a garage that is approximately a 10 minute drive from our venue. Parking: We have a dedicated car park that is approximately a 300m walk to the training venue. There is no additional cost to use this parking. We accept no responsibility for any personal loss or theft while you are on our training courses or premises. Please ensure to keep your personal belongings safe at all times. What is required from you: All courses are delivered in English, you must have a basic understanding of the English language to attend. There is a requirement for you to show that you are capable of performing the skills you are taught on the course, due to this you will need to be physically able to demonstrate all practical elements of the course. Dress: As a company we pride ourselves on running immersive & practical training courses. You will often be expected to kneel & work outdoors, please dress appropriately. Identification: As we deliver Ofqual accredited courses, there is a requirement for you to show a form of ID on the first day of the course. This could be; a driving license, passport or something that clearly shows who you are. Timings: All of our courses have a minimum training time of six hours a day, we will often advertise a course as seven hours to include break times. On occasion it is required to go over the scheduled times, however this will always be discussed with the group on the day. Trainer: During your course you will have a designated trainer for the duration. They are there not only to assess for the qualification, but to offer you guidance and support throughout. Security: We accept no responsibility for any personal loss or theft while you are on our training courses or premises. Please ensure to keep your personal belongings safe at all times.

Qualsafe Level 3 Award in First Response Emergency Care (FREC3)
Delivered In-Person in East Sussex, + more
£360

CITB TEMPORARY WORKS COORDINATORS REFRESHER

5.0(7)

By Safehouse Health And Safety Consultants Ltd

Introduction: “Co-ordinating the temporary works process” This two day course is designed to assist those on site who have responsibility for managing all forms of temporary works. It is also designed to give confidence to senior management and those who engage contractors have reached an assessed standard of knowledge. The course has the support of a number of organisations: Temporary Works Forum CECA, UKCG, HSE and FMB. The support of these organisations offers transferability of the course within industry.Temporary works are usually safety and business-critical and require careful co-ordination. An accepted way of achieving this is through the adoption of the management process outlined in BS5975, which introduces the temporary works co-ordinator (TWC) as a key figure. This course explains the role and the overall management context within which it sits.High risk can occur on small as well as larger sites hence understanding the essentials of good safety risk management, as outlined in BS5975, is relevant for projects of all sizes. This course will give the delegate thorough knowledge of the Temporary Works Co-ordinator role however this does not alone make a delegate competent, as this requires other attributes e.g. experience. Aims and Objectives: This course is not a temporary works awareness course. It is only concerned with the process of co-ordination of temporary works, commonly expressed through the role of the Temporary Works Co-ordinator. Attendance does not confer competency as a Temporary Works Co-ordinator.The course gives emphasis, throughout, to: – The importance of communication, co-ordination, co-operation and competency. The ‘4Cs’. – Risk management: safety and also business relatedAllowing the Temporary Works Co-ordinator (TWC) to: – Understand the need for and duties of a TWC – Understand the role of others – Have a detailed knowledge and understanding of BS5975 in respect of this role. Assessment: The method of assessment will be by multiple-choice questions at the end of the course as well as being expected to be interactive during the course.Course Attendance:Delegates are required to attend both sessions, since without full attendance and achievement in the examination the Temporary Works Co-ordinator Training Course cannot be made.Delegates must attend the days in order and, where not on consecutive days, must complete the course within two weeks. Delegates unable to attend both days due to extenuating circumstances (e.g. certificated sickness) will need to enrol onto a new course in order to maintain continuity of learning outcomes and attend both days again. It is expected that experienced and competent Temporary Works Co-ordinators will attend this course. Competence comes from a mixture of education, training and experience and should be judged by an appropriate senior individual, usually referred to as the Designated Individual (DI). Training is considered an essential element of Temporary Works Co-ordinator competence. Background Publications: This course, including its group work and exercises, is constructed around BS5975:2008 +A1:2011. For Open Courses Delegates should bring a copy with them in order not to be significantly disadvantaged. For in house courses it is expected that the Tutor will tailor the course around the organisation procedures,providing they are comprehensive and follow the philosophy of BS5975. In these cases delegates will need a copy of their own procedures. In the absence of adequate procedures delegates will need a copy of the BS itself.Although the following is not mandatory, delegates may find the following useful– BS EN12811-1:20031 Temporary works equipment. Scaffolds. Performance requirements and general design– BS EN12812:2008. Falsework ‐ performance requirements and general design– BS EN12813:2004. Temporary works equipment. Load bearing towers of prefabricated components. Particular methods of structural design– NASC TG20/13 plus supplement 1– NASC TG9:12

CITB TEMPORARY WORKS COORDINATORS REFRESHER
Delivered In-Person in Barnsley
£225

First Aid at Work

5.0(50)

By Pochat Training

QA Level 3 Award In First Aid At Work (RQF) Three-day course Gives learners the knowledge and skills to be a first aider Recommended by HSE for high risk workplaces Course Contents: The Roles and Responsibilities of an Emergency First Aider Assessing an Incident Minor Injuries Cuts, Grazes and Bruises Minor Burns and Scalds Managing an Unresponsive Casualty CPR Safe Use of an AED (Automated External Defibrillator) Choking Seizures Wounds and Bleeding Shock Eye Injuries Angina Heart Attack Stroke Asthma Diabetes Anaphylaxis Head Injuries Spinal Injuries Chest Injuries Fractures Sprains, Strains and Dislocations Poisoning Benefits of this course: 1.1 million workers in Britain had an accident at work in 2014/2015 Of those, 2,700 were from the East Midlands On average, one out of every 370 people received an injury at work The estimated cost of injuries and ill health last year was £15 billion The Health and Safety (First Aid) Regulations 1981 require all employers to make arrangements to ensure their employees receive immediate attention if they are injured or taken ill at work. This includes carrying out a risk assessment, appointing a suitable amount of first aiders and providing adequate first aid training Typically, first aiders will hold a valid certificate in either First Aid at Work (FAW) or Emergency First Aid at Work (EFAW) Our QA Level 3 Award in First Aid at Work (RQF) - FAW - training course is the one recommended for first aiders in a high risk workplace Having the correct first aid provision in the workplace is not just a legal requirement, it is incredibly important for the safety of all members of staff! As this is a Regulated Qualification, employers can book this course for their employees in the safe knowledge that they have fulfilled their legal responsibilities for providing quality first aid training, without having to undertake any lengthy due diligence checks Accredited, Ofqual regulated qualification: Our First Aid at Work (FAW) course is a nationally recognised, Ofqual regulated qualification accredited by Qualsafe Awards.This means that you can be rest assured that your First Aid at Work Certificate fulfills the legal requirements and is a very good way to make sure you and your employees are trained in First Aid, having the ability to save lives should the situation occur.The Ofqual Register number for this course is 603/2384/X

First Aid at Work
Delivered In-Person in Chesterfield + more
£260 to £275

CITB SSSTS (Site Supervisor Safety Training Scheme)

By 2020 Training

This two-day Site supervision safety training scheme (SSSTS) course is designed for those who have, or are about to acquire, supervisory responsibilities. The course covers all relevant legislation and other aspects which affect safe working in the building, construction and civil engineering industries. It is delivered interactively including group and individual activities. It highlights the need for risk assessment in the workplace, the implementation of the necessary control measures, and adequate communication to sustain a health and safety culture among the workforce. The Aim of the course is to help site supervisors to supervise health and safety on site in accordance with current legal provisions and within the context of their role. They should develop an understanding of responsibility and accountability for site health, safety and welfare of workers on site and be able to recognise that a safe site is efficient, economical, productive and environmentally friendly. At the start of each course, delegates will be provided with their own copy of the mandatory publications: (Construction site supervision and Toolbox talks) The course is broken down into 5 learning areas Legal and management Health and welfare General safety High risk activities Environment

CITB SSSTS (Site Supervisor Safety Training Scheme)
Delivered In-Person in Hull + 2 more + more
£268

3 Day First Aid at Work Initial

5.0(52)

By Direct Training (GB) Ltd

A Health & Safety Executive Approved course that complies with First Aid Regulations 1981 and includes AED training. This is an in-depth course that will take you through a wide range of injuries and illnesses that occur in the workplace. Who Should Attend? People that are in high-risk work environments. Nominees by an employer who deems that their business requires a First Aider. Course Content Health & Safety Using a First Aid Kit Incident Management Resuscitation / CPR - Adult, Child, Baby AED Familiarisation Recovery Position Choking - Adult, Child, Baby Burns & Scalds Poisoning including Anaphylaxis Epilepsy Shock Bleeding & Nose Bleeds Asthma Head Injuries Fractures, Sprains & Strains Many Other Specific Conditions Course Duration: Three Days (18 Hours) Certification Independent qualified assessors carry out the assessments. Each delegate that passes will receive a Certificate valid for Three years.

3 Day First Aid at Work Initial
Delivered In-Person
£219

City & Guilds Level 2 Award in Working in High Risk Confined Spaces - 6160-03

By Vp ESS Training

City & Guilds Level 2 Award in Working in High Risk Confined Spaces - 6160-03 - This course is designed to provide delegates that need to enter medium and high risk confined spaces with an in-depth understanding of legislation, regulations and safe systems of work. This course includes recognising all risk levels of confined spaces. Book via our website @ https://www.vp-ess.com/training/confined-spaces/6160-03-city-and-guilds-level-2-award-in-working-in-high-risk-confined-spaces/ or via email at: esstrainingsales@vpplc.com or phone on: 0800 000 346

City & Guilds Level 2 Award in Working in High Risk Confined Spaces - 6160-03
Delivered In-Person in Aberdeen + 9 more or UK WideFlexible Dates
£620

City & Guilds Level 3 Award in Control Entry and Arrangements for Confined Spaces (High Risk) - 6160-04

By Vp ESS Training

City & Guilds Level 3 Award in Control Entry and Arrangements for Confined Spaces (High Risk) - 6160-04 - This course is designed to provide delegates that need to enter medium and high risk confined spaces with an in-depth understanding of legislation, regulations and safe systems of work. This course includes recognising all risk levels of confined spaces. Book via our website @ https://www.vp-ess.com/training/confined-spaces/6160-04-level-3-award-in-control-entry-and-arrangements-for-confined-spaces-(high-risk)/ or via email at: esstrainingsales@vpplc.com or phone on: 0800 000 346

City & Guilds Level 3 Award in Control Entry and Arrangements for Confined Spaces (High Risk) - 6160-04
Delivered In-Person in Aberdeen + 9 more or UK WideFlexible Dates
£585

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems

By Airborne Environmental Consultants Ltd

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems is there to provide background and an overview of the risk of Legionella infection and how it can be controlled in Evaporative Cooling and other high risk Industrial type systems. It is a requirement of this course that candidates have successfully completed P901 - Legionella- Management and Control of Building Hot and Cold Water Services. Where both P901 and P903 courses are run on subsequent days or as a combined course then this prerequisite is waived.

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems
Delivered in Manchester + 1 more or OnlineFlexible Dates
£285

FOOD SAFETY (REFRESHER), LEVEL 2

5.0(50)

By Pochat Training

QA Level 2 Award In Food Safety (Refresher) (RQF) Face to Face: Half day course Virtual Classroom: Spread over 2 sessions of 2½ hr duration Suitable for those who have previously done an Ofqual regulated course in Food Safety in Catering, for Retail and for Manufacturing Reminds learners about the importance of Food Safety and how to ensure food is safe for consumption Course Contents: Responsibilities of food handlers Types of contamination Causes of cross contamination Types of Contamination and the Associated Risks Keeping the work area and equipment clean and tidy Pest control Sources of food poisoning People at higher risk of food poisoning High risk foods Hazard Analysis and Critical Control Point (HACCP) Personal hygiene in food safety Safe temperatures for food processing Food spoilage Storage and deliveries Benefits of this course: Businesses have a duty to their customers to produce food that is safe for consumption. There are one million cases of food poisoning in the UK each year. How much can you remember from when you did your original course? From our experience, people remember very little one year later - let alone longer than that The Food Standards Agency says that 'Food business operators are required by law, to ensure that food handlers receive appropriate supervision and instruction/training in food hygiene in line with their work activity and should enable them to handle food safely’. Our QA Level 2 Award in Food Safety (Refresher) (RQF) is a nationally accredited qualification especially suitable for people working in, or planning to work in, the food retail industry, and complies with the training regulations. Doing this Ofqual regulated, nationally accredited course ensures that nothing of importance is left out of your memory, and that you are able to produce or sell food that is fit for human consumption Accredited, Ofqual regulated qualification: Our Food Safety in Catering training course is a nationally recognised, Ofqual regulated qualification accredited by Qualsafe Awards. This means that you can be rest assured that your Food safety in Catering certificate fulfils the legal requirements and is a very good way to make sure your employees are trained in Food Safety. The Ofqual Register number for this course is 603/4311/4

FOOD SAFETY (REFRESHER), LEVEL 2
Delivered in Chesterfield or Online + more
£85

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems Online

By Airborne Environmental Consultants Ltd

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems is there to provide background and an overview of the risk of Legionella infection and how it can be controlled in Evaporative Cooling and other high risk Industrial type systems. It is a requirement of this course that candidates have successfully completed P901 - Legionella- Management and Control of Building Hot and Cold Water Services. Where both P901 and P903 courses are run on subsequent days or as a combined course then this prerequisite is waived.

BOHS P903 - Management and control of evaporative cooling and other high risk industrial systems Online
Delivered in Manchester + 1 more or OnlineFlexible Dates
Price on Enquiry