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Pcsk9 Education And Research Forum

pcsk9 education and research forum

Alcester

Reducing low density lipoprotein (LDL) cholesterol is the priority in managing patients with severe dyslipidaemia (cholesterol abnormality) and at high risk of cardiovascular (CV) death and disability. Yet even when treated with potent statins, many patients fail to achieve LDL-cholesterol targets and therefore their risk of accelerated atherosclerosis and CV death remains high. This problem is particularly critical in patients with familial hypercholesterolaemia (FH) (the most commonly occurring genetic condition in the world). People with FH typically have very high LDL cholesterol levels on treatment, and consequently, are at very high risk of premature and sudden CV death, myocardial infarction and stroke. Additionally, some patients are unable to tolerate statins – particularly at higher doses – and, therefore, do not achieve LDL-cholesterol goals. What is the importance of PCSK9? Discovered in 2003,1 PCSK9 is a protein made by the liver which increases the removal of LDL receptors from the surface of liver cells. These LDL receptors are critically important in removal of serum LDL-cholesterol from the circulation. People with so-called ‘gain of function’ PCSK9 mutations over-express PCSK9, and therefore have very high plasma levels of LDL cholesterol and are at very risk of atherosclerosis and CV mortality and morbidity.2 In contrast, people with so-called ‘loss of function’ PCSK9 mutations, have very LDL cholesterol levels and reduced risk for heart disease.3 What is PCSK9 inhibition? Different approaches to lowering PCSK9 are now licensed. These include fully human monoclonal antibodies (alirocumab, evolocumab) and a small-interfering RNA therapy (inclisiran). Trials show that these PCSK9 inhibitors reduce LDL cholesterol levels by about 50-60 percent - a significantly greater effect than that achieved with currently available therapies – either when given alone or in combination. These LDL cholesterol lowering effects have been consistently across a broad group of patients, including those with familial hypercholesterolaemia in clinical trials.4 Which clinical settings will benefit from the availability of PCSK9 inhibitors? These treatments offer the potential to reduce cardiovascular risk in patients whose clinical needs cannot be satisfied by current therapy. These include: Patients with familial hypercholesterolaemia – an inherited disorder of lipid metabolism with a very high risk of early CV death or morbidity, if not diagnosed or treated early Patients who cannot tolerate statins, who therefore remain at high risk of CV events such as heart attacks and strokes Patients with established heart disease who have not achieved LDL-cholesterol goals despite current therapies

Park Education And Training Centre

park education and training centre

Park Education & Training Centre was registered with the Registrar of Companies for England and Wales in 2007 as a private college. Hundreds of bright, ambitious students have passed through our doors, leaving a bit of themselves behind when they head off to that first job or university. We are proud of the institution they helped build. We are an accredited and approved examination centre for Pearson Edexcel Examination Board and NCFE Examination Board. We want to be known as a caring, friendly, culturally sensitive, well qualified and professional team of health campaigners, educationists and trainers. Your future is our concern. Our membership is growing at a steady pace. With this growth, we have been able to accomplish more, and have a larger impact upon our community. We welcome you with open arms. Park Education & Training Centre offers a range of courses relevant to the job market, which at the same time facilitate smooth progression onto further studies/ training or entry into higher education. This practical approach, seen in our emphasis on Health Studies, Functional Skills in English, Mathematics and Information Technology provides the student a firm base for future success. The ultimate accolade for us as trainers is the success of our students in their course (s) of choice; manifest in our profound belief in and meticulous attention to individual development programmes. Our qualifications are recognised worldwide by both public and private sector Employers/Agencies /Universities