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29 Educators providing Metabolism courses

BWT UK Limited

bwt uk limited

4.2(31)

High Wycombe

Water is our life elixir and at the same time a limited resource. BWT advocates the sustainable and responsible use of the precious resources of our blue planet. Water is our mission. It was the chemist Henry Cavendish (1731 – 1810), who discovered the composition of water, when he experimented with hydrogen and oxygen and mixed these elements together to create an explosion (oxyhydrogen effect). In 1811 the Italian physician Amedeo Avogadro finally found the H2O formula for water. Although water has a simple molecular structure, it nevertheless has unique physical properties. It is the only element that exists on our planet in a solid, liquid and gaseous aggregate state. It is these special properties that make water so fascinating and so important for all creatures. Water has 775 times the density of air. This fact causes the ‘buoyancy’ effect, which enables us - and most mammals - to swim. Many substances expand when they are subjected to heat and reduce their density at the same time; conversely, they increase their density when cooled down. When a liquid is cooled, the colder part sinks to the bottom. The freezing process of water is the other way round. Water reaches its maximum density at 4 degrees Celsius, which is exactly 0.999973 kg/l. Ice weighs 0.91 kg/l – which is the reason why icebergs float. This also explains why frozen water bottles explode and why fish can survive in a frozen lake. They live at the bottom where the water is the heaviest, as the temperature there is approximately 4 degrees Celsius. Water is a very bad heat conductor. This property is of utmost importance for the global climate. Water can actually store a lot of heat, which it then releases again during the cold season. In the warm season, however, it prevents excessive heating. In this way water moderates the differences in temperature. If one cubic centimetre of water evaporates (at approx. 100 degrees Celsius), its volume expands to 1243 cubic centimetres (vapour pressure) - a process that formed the basis of the construction of the steam engine; this machine eventually gave rise to the Industrial Revolution. The physical and chemical properties of water make it a universal solvent and means of transport, which is integrated into all cycles of nature, both micro- and macroscopic. Without water, for example, there would be no circulation of nitrogen or phosphorous - both essential elements in the biosphere - as there is no way for the corresponding ions to be transported. Water can dissolve salts and feed these in dissolved form to plants. Plants then use these ions as nutrients and release the water they don’t need for their nitrogen metabolism into the atmosphere. This small water cycle is as important as the large one - without it, and therefore without water, there would be no life.

Pcsk9 Education And Research Forum

pcsk9 education and research forum

Alcester

Reducing low density lipoprotein (LDL) cholesterol is the priority in managing patients with severe dyslipidaemia (cholesterol abnormality) and at high risk of cardiovascular (CV) death and disability. Yet even when treated with potent statins, many patients fail to achieve LDL-cholesterol targets and therefore their risk of accelerated atherosclerosis and CV death remains high. This problem is particularly critical in patients with familial hypercholesterolaemia (FH) (the most commonly occurring genetic condition in the world). People with FH typically have very high LDL cholesterol levels on treatment, and consequently, are at very high risk of premature and sudden CV death, myocardial infarction and stroke. Additionally, some patients are unable to tolerate statins – particularly at higher doses – and, therefore, do not achieve LDL-cholesterol goals. What is the importance of PCSK9? Discovered in 2003,1 PCSK9 is a protein made by the liver which increases the removal of LDL receptors from the surface of liver cells. These LDL receptors are critically important in removal of serum LDL-cholesterol from the circulation. People with so-called ‘gain of function’ PCSK9 mutations over-express PCSK9, and therefore have very high plasma levels of LDL cholesterol and are at very risk of atherosclerosis and CV mortality and morbidity.2 In contrast, people with so-called ‘loss of function’ PCSK9 mutations, have very LDL cholesterol levels and reduced risk for heart disease.3 What is PCSK9 inhibition? Different approaches to lowering PCSK9 are now licensed. These include fully human monoclonal antibodies (alirocumab, evolocumab) and a small-interfering RNA therapy (inclisiran). Trials show that these PCSK9 inhibitors reduce LDL cholesterol levels by about 50-60 percent - a significantly greater effect than that achieved with currently available therapies – either when given alone or in combination. These LDL cholesterol lowering effects have been consistently across a broad group of patients, including those with familial hypercholesterolaemia in clinical trials.4 Which clinical settings will benefit from the availability of PCSK9 inhibitors? These treatments offer the potential to reduce cardiovascular risk in patients whose clinical needs cannot be satisfied by current therapy. These include: Patients with familial hypercholesterolaemia – an inherited disorder of lipid metabolism with a very high risk of early CV death or morbidity, if not diagnosed or treated early Patients who cannot tolerate statins, who therefore remain at high risk of CV events such as heart attacks and strokes Patients with established heart disease who have not achieved LDL-cholesterol goals despite current therapies

Training Express

training express

5.0(1)

London

About Us Training Express is a premier course provider, established by a committed team of experts working across the UK. We deliver accredited certification and training to UK businesses aiming to enhance organisational performance. Our extensive courses span a wide range of sectors and industries, with a strong emphasis on promoting high standards of food hygiene, business wellbeing, and workplace safety. Our goal is to assist businesses in making smarter decisions regarding their management of in-house safety standards and regulations by bringing in specialists to guide you every step of the way. We pride ourselves on continuously improving our course quality and catalogue, consistently introducing new opportunities for our learners to maximise their professional development. Quality is paramount to us, which is why we only collaborate with trainers and professionals we can trust. We employ only the most qualified experts to support you in your studies, ensuring a high standard of service every time. This dedication has led us to become one of the most respected training providers, renowned for helping businesses ensure workplace proficiency, professionalism, and safety. Our Vision Training Express has one clear vision: to enhance workplace standards for organisations across the UK. Our mission and values are centred on raising awareness regarding professional compliance, competency, and preparedness in matters of health and safety. This means that we endeavour to help everyone we work with take steps towards a safer and more productive working environment. The ultimate goal: to boost business performance, ensure safer working environments, and uphold a high standard of professionalism in businesses nationwide. Our Aim As a leading health and safety training course provider, we strive to improve workplace standards, awareness, quality, and compliance. We offer on-site tuition to ensure a user-friendly service that will equip you with the information needed to effectively train staff on industry best practices. Each course is accredited and approved by a professional, guaranteeing quality training material in accordance with industry standards. We also aim to maintain complete transparency, and you can learn about your rights as a trainee and how we manage and store your data in our detailed Business and Privacy Policy. Should you wish to know more about our terms of service, please feel free to contact us at any time via email or phone. Our customer service team is always on hand to address any issues or queries you may have. Why choose us At Training Express, we are confident that our professional dedication, user-friendly platform and commitment to delivering quality training sets us apart from our competitors. Our team is experts in their field and our specially curated courses are designed to make learning online as flexible and efficient as possible. Our trusted, high quality and affordable online courses are designed to train individuals to become experts in their field. * Accredited Certification * Meets UK & EU Standards * Developed by Qualified Professionals * Engaging Audio Visual Training * Instant Course Access * Study Wherever, Whenever * Instant Digital Certificate * Premium Support: Live Chat, Email, Telephone