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455 Educators providing Courses delivered On Demand

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Pcsk9 Education And Research Forum

pcsk9 education and research forum

Alcester

Reducing low density lipoprotein (LDL) cholesterol is the priority in managing patients with severe dyslipidaemia (cholesterol abnormality) and at high risk of cardiovascular (CV) death and disability. Yet even when treated with potent statins, many patients fail to achieve LDL-cholesterol targets and therefore their risk of accelerated atherosclerosis and CV death remains high. This problem is particularly critical in patients with familial hypercholesterolaemia (FH) (the most commonly occurring genetic condition in the world). People with FH typically have very high LDL cholesterol levels on treatment, and consequently, are at very high risk of premature and sudden CV death, myocardial infarction and stroke. Additionally, some patients are unable to tolerate statins – particularly at higher doses – and, therefore, do not achieve LDL-cholesterol goals. What is the importance of PCSK9? Discovered in 2003,1 PCSK9 is a protein made by the liver which increases the removal of LDL receptors from the surface of liver cells. These LDL receptors are critically important in removal of serum LDL-cholesterol from the circulation. People with so-called ‘gain of function’ PCSK9 mutations over-express PCSK9, and therefore have very high plasma levels of LDL cholesterol and are at very risk of atherosclerosis and CV mortality and morbidity.2 In contrast, people with so-called ‘loss of function’ PCSK9 mutations, have very LDL cholesterol levels and reduced risk for heart disease.3 What is PCSK9 inhibition? Different approaches to lowering PCSK9 are now licensed. These include fully human monoclonal antibodies (alirocumab, evolocumab) and a small-interfering RNA therapy (inclisiran). Trials show that these PCSK9 inhibitors reduce LDL cholesterol levels by about 50-60 percent - a significantly greater effect than that achieved with currently available therapies – either when given alone or in combination. These LDL cholesterol lowering effects have been consistently across a broad group of patients, including those with familial hypercholesterolaemia in clinical trials.4 Which clinical settings will benefit from the availability of PCSK9 inhibitors? These treatments offer the potential to reduce cardiovascular risk in patients whose clinical needs cannot be satisfied by current therapy. These include: Patients with familial hypercholesterolaemia – an inherited disorder of lipid metabolism with a very high risk of early CV death or morbidity, if not diagnosed or treated early Patients who cannot tolerate statins, who therefore remain at high risk of CV events such as heart attacks and strokes Patients with established heart disease who have not achieved LDL-cholesterol goals despite current therapies

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Safer At Work- Newcastle

safer at work- newcastle

5.0(26)

Safer At Work believes that GWO training should be more than a tick-box exercise, our teams have designed our training and skills boot camps (government-funded courses) to include realistic training environments to prepare individuals to work more effectively in the wind industry.   In addition to GWO training, we offer a session and subsequent support on mental health. We are passionate about this because we believe people's ability to perform and act safely in a high-risk environment can be compromised if they are not in good mental health.

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Cambridge Consultancy Research & Training

cambridge consultancy research & training

London

Welcome to Cambridge Consultants People We are a global team of 800 bright, talented people – united by the ambition to turn brilliant and radical ideas into technologies, products and services that are new to the world. Technology We expand the boundaries of technology innovation by tackling the tough, high-risk challenges that bring sustained competitive advantage and market leadership for you. Impact We are trusted by some of the world’s biggest brands and most ambitious start-ups to realise their most critical technology-based aspirations – and we’ve been doing it for 60 years.

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Arion Training & Development

arion training & development

London

Russ is the Managing Director and Safety Consultant of Arion Ltd, highly qualified in health and safety and its associated disciplines. He takes pride in being highly active within our integrated consultancy. Russ specialises in high risk safety management, accident investigation, and safety consultancy and services – though, like all of our employees, he has extensive knowledge on all health and safety! He is a fully qualified teacher that designs and instructs our training courses and fire audits. Russ views his role within the company as both an active advisor and instructor, there to help clients meet all of their needs.

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Ig Academy

ig academy

The risks of loss from investing in CFDs can be substantial and the value of your investments may fluctuate. 75% of retail client accounts lose money when trading CFDs, with this investment provider. CFDs are complex instruments and come with a high risk of losing money rapidly due to leverage. You should consider whether you understand how this product works, and whether you can afford to take the high risk of losing your money. CFD Accounts provided by IG International Limited. IG International Limited is licenced to conduct investment business and digital asset business by the Bermuda Monetary Authority. IG provides an execution-only service. The information in this site does not contain (and should not be construed as containing) investment advice or an investment recommendation, or an offer of or solicitation for transaction in any financial instrument. IG accepts no responsibility for any use that may be made of these comments and for any consequences that result. The information on this site is not directed at residents of the United States and is not intended for distribution to, or use by, any person in any country or jurisdiction where such distribution or use would be contrary to local law or regulation. IG International Limited is part of the IG Group and its ultimate parent company is IG Group Holdings Plc. IG International Limited receives services from other members of the IG Group including IG Markets Limited.

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Horizon 360

horizon 360

Horizon 360 provides courses for accountants & finance professionals on a range of topics to keep on top of the changing rules and regulationsLand and property projects and transactions are usually high value and inevitably high risk from a VAT point of view. This area of VAT is complex Errors are easy to make, often impossible to correct, and can lead to unanticipated costs and penalties. This VAT on Land, Property and Construction course provides a full explanation of all the VAT rules for commercial, charity and residential construction, refurbishment and supply, as well as common supplies between landlords and tenants. It will equip the delegate to plan projects VAT effectively, and avoid VAT traps. A good basic knowledge of VAT is assumed.

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Vp ESS Training

vp ess training

Wellingborough

With over 25 years of experience, ESS stands at the forefront of safety training, delivering expert instruction to thousands of delegates each year across a network of specialised training centres. Our commitment to safety excellence is reflected in the qualifications of our trainers, who uphold the highest industry standards and ensure that every delegate receives exceptional purposeful training.  Each of our training centres are approved by City & Guilds and RoSPA (The Royal Society for the Prevention of Accidents), guaranteeing that our services meet the highest professional benchmarks. All ESS Training centres are both City & Guilds and RoSPA approved. w: https://www.vp-ess.com/training/ t: 0800 000 346 e: esstrainingsales@vpplc.com ESS Training work alongside key qualification bodies such as RoSPA, City & Guilds, Qualsafe, ECITB, EUSR and many more to provide a range of accredited courses ranging from Confined Space Training and Manual Handling to Working at Heights, First Aid, Utility Detection, New Roads and Streetworks Training as well as virtual and e-learning modules.  We can provide tailored training solutions to satisfy your requirements for both theoretical and practical assessments while our qualified and experienced trainers are constantly on hand to provide support and guidance during the training. All Locations Aberdeen,  Glasgow,  Castleford (Wakefield), Middlesbrough,  Wellingborough,  Manchester,  Southampton,  Heathrow (London West) Exeter,  Rainham (London East)

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Sanofi

sanofi

Reading

Building on Sanofi’s legacy of many years of fighting cardiovascular disease, we deliver therapeutic solutions for cardiovascular conditions to patients at high risk for cardiac events (such as a heart attack) and strive to enhance the quality of life for such patients. Consumer Healthcare Self-care can enhance wellbeing, prevent disease, curb illness and restore health. Self-care contributes significantly not only to better health, but more sustainable healthcare systems and will become increasingly important in the years to come. In the UK, we have a 50-year heritage in this area. We leverage our strengths in science, together with our world-class pharmaceutical quality standards, to deliver consumer-driven, medicines and products across a number of key categories, including digestive health, pain care, allergy and vitamins and mineral supplements.

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Gs Security International

gs security international

Do you feel safe in your daily life? Contemporary society is increasingly unstable, but are you able to manage the various threats of our age? These are just some of the various questions we ask ourselves every day, living in a period in which security is a subject much discussed, and that is why we have designed for you a range of courses on security depending on your needs or those of your company. GS SECURITY INTERNATIONAL LLC is a group with a long experience, a company founded in Ukraine expert in consulting services in training of security operators in high risk areas and in anti-terrorism consultancy, able to cover all the crisis areas all over the world boasting the best consultants and professionals in the field for every solution.

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SAY Women

say women

5.0(2)

Glasgow

SAY Women offers safe semi-supported accommodation and emotional support for young women aged 16 to 25 who are survivors of sexual abuse, rape or sexual assault and who are homeless, or threatened with homelessness. SAY Women was established in 1991 in response to CHAR research that found 4 in 10 young women who were homeless had become so due to sexual abuse. The research recognised the complex needs of young women in this position and the high risk of ongoing targeting from perpetrators due to their vulnerable circumstances. We are a charity of women supporting women who are survivors of men’s sexual violence. Using the framework of the Judith Herman model: Establishing Safety, Mourning & Remembering, Reconnection and Move On, we operate the Social Model of support. This concentrates on the experience of abuse as the issue, and recognises that the behaviours that survivors have had to use, such as self-harm and anger, are coping strategies. Collage.jpg Support for the young women is offered in the form of semi-independent living in our Accommodation Project, alongside support to prepare for a more independent lifestyle, as well as looking at the difficulties surrounding their childhood sexual abuse. They work towards moving into their own tenancy, while we offer ongoing support at our Resource Service with emotional and mental health difficulties, plus groupwork, events, activities and help with practical issues. The support we provide is flexible and varies according to what each young woman needs, so she is always in control and can access the service at a pace that suits her.

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