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Pcsk9 Education And Research Forum

pcsk9 education and research forum

Alcester

Reducing low density lipoprotein (LDL) cholesterol is the priority in managing patients with severe dyslipidaemia (cholesterol abnormality) and at high risk of cardiovascular (CV) death and disability. Yet even when treated with potent statins, many patients fail to achieve LDL-cholesterol targets and therefore their risk of accelerated atherosclerosis and CV death remains high. This problem is particularly critical in patients with familial hypercholesterolaemia (FH) (the most commonly occurring genetic condition in the world). People with FH typically have very high LDL cholesterol levels on treatment, and consequently, are at very high risk of premature and sudden CV death, myocardial infarction and stroke. Additionally, some patients are unable to tolerate statins – particularly at higher doses – and, therefore, do not achieve LDL-cholesterol goals. What is the importance of PCSK9? Discovered in 2003,1 PCSK9 is a protein made by the liver which increases the removal of LDL receptors from the surface of liver cells. These LDL receptors are critically important in removal of serum LDL-cholesterol from the circulation. People with so-called ‘gain of function’ PCSK9 mutations over-express PCSK9, and therefore have very high plasma levels of LDL cholesterol and are at very risk of atherosclerosis and CV mortality and morbidity.2 In contrast, people with so-called ‘loss of function’ PCSK9 mutations, have very LDL cholesterol levels and reduced risk for heart disease.3 What is PCSK9 inhibition? Different approaches to lowering PCSK9 are now licensed. These include fully human monoclonal antibodies (alirocumab, evolocumab) and a small-interfering RNA therapy (inclisiran). Trials show that these PCSK9 inhibitors reduce LDL cholesterol levels by about 50-60 percent - a significantly greater effect than that achieved with currently available therapies – either when given alone or in combination. These LDL cholesterol lowering effects have been consistently across a broad group of patients, including those with familial hypercholesterolaemia in clinical trials.4 Which clinical settings will benefit from the availability of PCSK9 inhibitors? These treatments offer the potential to reduce cardiovascular risk in patients whose clinical needs cannot be satisfied by current therapy. These include: Patients with familial hypercholesterolaemia – an inherited disorder of lipid metabolism with a very high risk of early CV death or morbidity, if not diagnosed or treated early Patients who cannot tolerate statins, who therefore remain at high risk of CV events such as heart attacks and strokes Patients with established heart disease who have not achieved LDL-cholesterol goals despite current therapies

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EasiLearning

easilearning

Callander

E-Learning enables busy professionals to complete essential training at a time and place that suits them. The production of quality interactive training is far from straightforward, and many trainees have become disillusioned with dull and boring e-learning courses. Which is where EasiLearning come in – with entertaining and engaging courses for professional users. Current online courses offered include: Anaphylactic Shock Standard refresher training in anaphylaxis Anaphylactic Shock Lite refresher training in anaphylaxis Clinical Nutrition Screening & Support (for ‘MUST’) Online training in Patient Group Directions (PGD) for the NHS Vaccination Training for Pharmacists Venepuncture Theory We offer versions tailored for both Community and Hospitals settings where required. We also have versions appropriate to where in the UK you are working, as there are some differences between the juristrictions of England, Wales, Scotland, N Ireland, Jersey etc. Free Guide offered: Hand Washing in a Clinical Setting EasiLearning will tailor this Guide for Clinical Organisations free of charge to help increase infection control and to promote our courses. Contact Us for further details Expanding List: The list of EasiLearning courses is expanding all the time. If you would like a subject we do not currently offer, go to Contact Us and let us know. However, the subject must be suitable for online learning and must be of interest to a wide audience. We also offer courses from a small number of other quality suppliers – see Training Resources Personalisation, Assessment & Tracking All EasiLearning online courses are tailored to the organisation with personalised introduction and a certificate with the organisation’s logo. Each trainee can print off their certificate on completion of the inbuilt assessment. The cloud based version of the courses use EasiLearning’s Train and TrackTM system, which gives management a unique weblink so they can track which trainees have passed the assessment and on what date together with a score where this is appropriate. No specialist IT infrastructure is required to make this version of the course work – commission to delivery is usually less than 2 weeks! Some customers already have an LMS and may choose either SCORM 1.2 or 1.3 version to have tracking and reporting done by the LMS. In either Web or SCORM versions, trainee completion data is available to be exported into e-personnel systems. We offer special versions for NHS England nLMS/OLM.

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Cambridge Biomedical Campus

cambridge biomedical campus

The Campus The Cambridge Biomedical Campus (CBC) is located at the heart of the UK’s and Europe’s leading life sciences cluster. We are a vibrant, international healthcare community and a global leader in medical science, research, education and patient care. By locating world-leading academic and industry scientists on the same site as the teaching hospitals of the University of Cambridge, we are creating the optimum environment for the rapid and effective translation of research into routine clinical practice. We succeed because of the strength of our ecosystem which allows ideas to develop and flourish. We have the physical space to accommodate new and expanding companies and the international connections to be the global hub for content and research.

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Kent & Medway Primary Care Training Hub

kent & medway primary care training hub

We are an all-encompassing workforce development and education network set up to support both medical and non-medical staff working in Primary Care and the Community within West Kent. We have been established in response to Health Education England’s desire to organise education and training in the community. WKEN is your local training hub and we are here to bring together and retain the talent we have. Our aim is to: Recruit; Train; Support; Retain We are working in partnership with Kent and Medway Clinical Commissioning Group (KM CCG) and Kent and Medway ICP to fulfil this ambition in the face of all the external and system changes challenging the primary care sector. Learn More

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Breathe And Bloom Community Interest Company

breathe and bloom community interest company

Old Snydale

have always been passionate about caring for and serving women during times in their life when they need extra support and guidance. I have over 15 years Midwifery experience, working in a busy NHS organisation, my roles over the years have included Labour Ward, Birth Centre, Mental Health Champion, Community, Breast Feeding Champion, Clinical Midwifery Educator and Preceptorship Midwife. After much thought and consideration, I decided to set up my own business after a flicker of constant knowing that it was time for me to move on and deliver the care and services, I know to truly help in a way I can do without being met with discouragement or money/time/staffing restraints.

Optident

optident

Ilkley

Optident has an extensive range of air abrasion units including the efficient and effective AquaCare Air Abrasion unit by Velopex.At Optident, both our products and our people are unique. We are extremely proud of our combined knowledge and experience and together we are dedicated to enhancing clinical excellence. As a team of motivated people who are forward-thinking and enthusiastic about bringing innovation to the dental industry, we believe in offering solutions and adding value. Shop our innovative products online and meet our experienced team today. We are also extremely proud to be an award-winning company, having won the title of both ‘Best Company’ and ‘Product Brand’ of the year at the Dental Industry Awards 2016.

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Dr Tharaka

dr tharaka

London

TV Doctor, Psychiatrist, High Performance Expert & Accredited Speaker. Hi, I’m Tharaka. People call me Dr T. I’m a Clinical Psychiatrist – ‘Mind Guy’ – gone Professional Speaker. I understand a thing or two about how people think, make decisions and take actions. I’m here to help corporations better understand and navigate the mind of their people and their clients in order to inform strategic behavioural change that drives greater progress – greater profit. I speak to Wealth, Automotive and Tech audiences on Emotional Intelligence and Cognitive Biases in order to help them improve their Personal Effectiveness, Interpersonal Trust & Sales skills, Leadership, Innovation and even Memory Power. When you manage the mind, you can manage your bottom line!

Clearmind International

clearmind international

At Clearmind we believe that REAL relationships are the foundation for an optimal life. Our founders, Duane and Catherine O’Kane, are a passionate, engaging and relatable husband and wife team whose mission is to accelerate personal evolution through the power of authentic connection. They are dedicated to practicing what they preach in all aspects of their personal and professional lives. Duane O’Kane founded Clearmind in 1991, after emerging from a deep clinical depression triggered by a personal relationship crisis and a series of losses, including his father by suicide. At the time he was a family therapist, and nothing in his extensive professional repertoire could adequately address the depth of this depression.

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Oxford Society of Oral Implantology

oxford society of oral implantology

The Oxford Society of Oral Implantology was inaugurated in October 2004.This event was marked by the creation of an annual comprehensive programme on implant and reconstructive surgery to be held in Oxford (UK) and Lille (France), extended over a period of one year.The one year certificate in Comprehensive Oral Implantology follows the guidelines of a leading French University with more than 20 years of internationally recognized teaching experience in implant dentistry. It takes the student beyond the teaching of routine mechanics of implant placement and standard restorative procedures. A meticulous basic science component related to implant and reconstructive surgery accompanies a closely integrated clinical chapter, guiding the student through all the intricate aspects of this medical discipline.

Medacs Healthcare

medacs healthcare

3.8(135)

Skipton

We provide a range of services including staffing, managed services, staff bank, occupational health, workforce consulting, social care and homecare through our specialist brands; Medacs Healthcare, Global Medics and Litmus Workforce Solutions. Medacs Global Group is a leading global healthcare workforce solutions provider. We provide a range of services including staffing, managed services, staff bank, occupational health, workforce consulting, social care and homecare through our specialist brands; Medacs Healthcare, Global Medics and Litmus Workforce Solutions. Established in 1990, we have an enviable reputation for providing high quality locum, temporary and permanent doctors, nurses, allied health professionals, clinical assessor and care workers. We are the largest provider of locum doctors to the NHS and largest supplier of specialist healthcare managed services outside of the United States. With operations across the United Kingdom, Ireland, Middle East, India, Australia and New Zealand, the Medacs Global Group will support you to deliver outstanding care wherever you are in the world.

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